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Case of the Week 323 
What's the most likely diagnosis?
- 10 year-old with abnormal skull radiograph
- Neuroblastoma
- Lytic phase of Paget disease
- Leptomeningeal cyst
- Metastatic prostate carcinoma
- Eosinophilic granuloma
Additional Images - Axial CT scan of the skull
Additional Images
Axial CT of the brain displayed with bone window
Answer:
5. Eosinophilic granuloma
More (Click Discussion Tab)
Eosinophilic Granuloma of the Skull
General Considerations
- Also known as eosinophilic granuloma(tosis)
- Proliferative disorder of the Langerhans cells
- Normally found in the skin (and a few other organs) and serve as antigen-presenting cells
- Rare diseases, affecting neonates up to adults
- 2:1 male to female predominance
- Prognosis
- Mortality and morbidity are associated with the clinical presentation and age of onset of the disease
- Worst prognosis for neonates presenting with the disseminated form
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LearningRadiology.com is an award-winning educational site aimed primarily at medical students and radiology residents-in-training, containing lectures, handouts, images, Cases of the Week, archives of case quizzes, flashcards of differential diagnoses and “most commons” lists, primarily in the areas of chest, GI, cardiac, and bone radiology.
